SPELL - Nematode

Citation	Sugi T, Nishida Y, Mori I. Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans. Nat Neurosci, 2011.
PubMed ID	21706021
Short Description	Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans. GEO Record: GSE28856 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00039792.ce.mr.csv
# of Conditions	12
Full Description	Animals cope with environmental changes by altering behavioral strategy. Environmental information is generally received by sensory neurons in the neural circuit that generates behavior. However, although environmental temperature inevitably influences an animal's entire body, the mechanism of systemic temperature perception remains largely unknown. We show here that systemic temperature signaling induces a change in a memory-based behavior in C. elegans. During behavioral conditioning, non-neuronal cells as well as neuronal cells respond to cultivation temperature through a heat-shock transcription factor that drives newly identified gene expression dynamics. This systemic temperature signaling regulates thermosensory neurons non-cell-autonomously through the estrogen signaling pathway, producing thermotactic behavior. We provide a link between systemic environmental recognition and behavioral plasticity in the nervous system. Experimental Details: WBPaper00039792:WT_0_h_rep1 WBPaper00039792:WT_4_h_rep1 WBPaper00039792:WT_0_h_rep2 WBPaper00039792:WT_4_h_rep2 WBPaper00039792:WT_0_h_rep3 WBPaper00039792:WT_4_h_rep3 WBPaper00039792:WT_0_h_rep4 WBPaper00039792:WT_4_h_rep4 WBPaper00039792:WT_1_h_rep1 WBPaper00039792:WT_2_h_rep1 WBPaper00039792:WT_1_h_rep2 WBPaper00039792:WT_2_h_rep2.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: response to temperature stimulus