| Citation | Youngman MJ, Rogers ZN, Kim DH. A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans. PLoS Genet, 2011. |
| PubMed ID | 21625567 |
| Short Description | A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans. GEO Record: GSE21784 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00038462.ce.mr.csv |
| # of Conditions | 9 |
Full Description
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The decline in immune function with aging, known as immunosenescence, has been implicated in evolutionarily diverse species, but the underlying molecular mechanisms are not understood. During aging in Caenorhabditis elegans, intestinal tissue deterioration and the increased intestinal proliferation of bacteria are observed, but how innate immunity changes during C. elegans aging has not been defined. Here we show that C. elegans exhibits increased susceptibility to bacterial infection with age, and we establish that aging is associated with a decline in the activity of the conserved PMK-1 p38 mitogen-activated protein kinase pathway, which regulates innate immunity in C. elegans. Our data define the phenomenon of innate immunosenescence in C. elegans in terms of the age-dependent dynamics of the PMK-1 innate immune signaling pathway, and they suggest that a cycle of intestinal tissue aging, immunosenescence, and bacterial proliferation leads to death in aging C. elegans. Experimental Details: WBPaper00038462:L4_rep1 WBPaper00038462:L4_rep2 WBPaper00038462:L4_rep3 WBPaper00038462:day_6_adults_rep1 WBPaper00038462:day_6_adults_rep2 WBPaper00038462:day_6_adults_rep3 WBPaper00038462:day_15_adults_rep1 WBPaper00038462:day_15_adults_rep2 WBPaper00038462:day_15_adults_rep3. |
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