|Citation||Asikainen S, Storvik M, Lakso M, Wong G. Whole genome microarray analysis of C. elegans rrf-3 and eri-1 mutants. FEBS Lett, 2007.|
|Short Description||Whole genome microarray analysis of C. elegans rrf-3 and eri-1 mutants. |
GEO Record: GSE8659 Platform: GPL200
Download gene-centric, log2 transformed data: WBPaper00031070.ce.mr.csv
|# of Conditions||9|
|Full Description||We performed genome wide gene expression analysis on L4 stage Caenorhabditis elegans rrf-3(pk1426) and eri-1(mg366) mutant strains to study the effects caused by loss of their encoded proteins, which are required for the accumulation of endogenous secondary siRNAs. Mutant rrf-3 and eri-1 strains exhibited 72 transcripts that were co-over-expressed and 4 transcripts co-under-expressed (>2-fold, P<0.05) compared to N2 wild type strain. Ontology analysis indicated these transcripts were over represented for protein phosphorylation and sperm function genes. These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in the endo-siRNA pathway, and furthermore suggests their involvement in additional biological processes.