SPELL - Nematode

Citation	Golden TR, Hubbard A, Dando C, Herren MA, Melov S. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell, 2008.
PubMed ID	18778409
Short Description	Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. GEO Record: GSE12290 Platform: GPL5859 Download gene-centric, log2 transformed data: WBPaper00032165.ce.mr.csv
# of Conditions	104
Full Description	There has been a great deal of interest in identifying potential biomarkers of aging. Biomarkers of aging would be useful to predict potential vulnerabilities in an individual that may arise well before they are chronologically expected, due to idiosyncratic aging rates that occur between individuals. Prior attempts to identify biomarkers of aging have often relied on the comparisons of long-lived animals to a wild-type control. However, the effect of interventions in model systems that prolong lifespan (such as single gene mutations or caloric restriction) can sometimes be difficult to interpret due to the manipulation itself having multiple unforeseen consequences on physiology, unrelated to aging itself. The search for predictive biomarkers of aging therefore is problematic, and the identification of metrics that can be used to predict either physiological or chronological age would be of great value. One methodology that has been used to identify biomarkers for numerous pathologies is gene expression profiling. Here, we report whole-genome expression profiles of individual wild-type Caenorhabditis elegans covering the entire wild-type nematode lifespan. Individual nematodes were scored for either age-related behavioral phenotypes, or survival, and then subsequently associated with their respective gene expression profiles. This facilitated the identification of transcriptional profiles that were highly associated with either physiological or chronological age. Overall, our approach serves as a paradigm for identifying potential biomarkers of aging in higher organisms that can be repeatedly sampled throughout their lifespan. Experimental Details: WBPaper00032165:12_days_old_tg115 WBPaper00032165:12_days_old_tg122 WBPaper00032165:12_days_old_tg132 WBPaper00032165:12_days_old_tg133 WBPaper00032165:12_days_old_tg139 WBPaper00032165:12_days_old_tg28 WBPaper00032165:12_days_old_tg29 WBPaper00032165:12_days_old_tg32 WBPaper00032165:12_days_old_tg36 WBPaper00032165:12_days_old_tg45 WBPaper00032165:12_days_old_tg6 WBPaper00032165:12_days_old_tg76 WBPaper00032165:12_days_old_tg77 WBPaper00032165:12_days_old_tg85 WBPaper00032165:12_days_old_tg90 WBPaper00032165:12_days_old_tg96 WBPaper00032165:12_days_old_tg98 WBPaper00032165:14_days_old_tg101 WBPaper00032165:14_days_old_tg11 WBPaper00032165:14_days_old_tg117 WBPaper00032165:14_days_old_tg126 WBPaper00032165:14_days_old_tg131 WBPaper00032165:14_days_old_tg24 WBPaper00032165:14_days_old_tg40 WBPaper00032165:14_days_old_tg43 WBPaper00032165:14_days_old_tg48 WBPaper00032165:14_days_old_tg50 WBPaper00032165:14_days_old_tg54 WBPaper00032165:14_days_old_tg56 WBPaper00032165:14_days_old_tg67 WBPaper00032165:14_days_old_tg82 WBPaper00032165:14_days_old_tg86 WBPaper00032165:14_days_old_tg93 WBPaper00032165:14_days_old_tg94 WBPaper00032165:16_days_old_tg103 WBPaper00032165:16_days_old_tg108 WBPaper00032165:16_days_old_tg113 WBPaper00032165:16_days_old_tg120 WBPaper00032165:16_days_old_tg128 WBPaper00032165:16_days_old_tg136 WBPaper00032165:16_days_old_tg137 WBPaper00032165:16_days_old_tg26 WBPaper00032165:16_days_old_tg30 WBPaper00032165:16_days_old_tg41 WBPaper00032165:16_days_old_tg46 WBPaper00032165:16_days_old_tg49 WBPaper00032165:16_days_old_tg60 WBPaper00032165:16_days_old_tg75 WBPaper00032165:16_days_old_tg79 WBPaper00032165:16_days_old_tg8 WBPaper00032165:16_days_old_tg88 WBPaper00032165:20_days_old_tg116 WBPaper00032165:20_days_old_tg121 WBPaper00032165:20_days_old_tg124 WBPaper00032165:20_days_old_tg129 WBPaper00032165:20_days_old_tg14 WBPaper00032165:20_days_old_tg20 WBPaper00032165:20_days_old_tg31 WBPaper00032165:20_days_old_tg35 WBPaper00032165:20_days_old_tg42 WBPaper00032165:20_days_old_tg44 WBPaper00032165:20_days_old_tg53 WBPaper00032165:20_days_old_tg58 WBPaper00032165:20_days_old_tg92 WBPaper00032165:20_days_old_tg97 WBPaper00032165:24_days_old_tg102 WBPaper00032165:24_days_old_tg105 WBPaper00032165:24_days_old_tg106 WBPaper00032165:24_days_old_tg114 WBPaper00032165:24_days_old_tg130 WBPaper00032165:24_days_old_tg33 WBPaper00032165:24_days_old_tg38 WBPaper00032165:24_days_old_tg59 WBPaper00032165:24_days_old_tg64 WBPaper00032165:4_days_old_tg100 WBPaper00032165:4_days_old_tg110 WBPaper00032165:4_days_old_tg111 WBPaper00032165:4_days_old_tg119 WBPaper00032165:4_days_old_tg123 WBPaper00032165:4_days_old_tg134 WBPaper00032165:4_days_old_tg138 WBPaper00032165:4_days_old_tg34 WBPaper00032165:4_days_old_tg52 WBPaper00032165:4_days_old_tg62 WBPaper00032165:4_days_old_tg87 WBPaper00032165:4_days_old_tg91 WBPaper00032165:4_days_old_tg95 WBPaper00032165:8_days_old_tg10 WBPaper00032165:8_days_old_tg104 WBPaper00032165:8_days_old_tg109 WBPaper00032165:8_days_old_tg112 WBPaper00032165:8_days_old_tg118 WBPaper00032165:8_days_old_tg125 WBPaper00032165:8_days_old_tg127 WBPaper00032165:8_days_old_tg135 WBPaper00032165:8_days_old_tg23 WBPaper00032165:8_days_old_tg37 WBPaper00032165:8_days_old_tg39 WBPaper00032165:8_days_old_tg47 WBPaper00032165:8_days_old_tg51 WBPaper00032165:8_days_old_tg57 WBPaper00032165:8_days_old_tg61 WBPaper00032165:8_days_old_tg83 WBPaper00032165:8_days_old_tg89.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: aging