| Citation | Budovskaya YV, Wu K, Southworth LK, Jiang M, Tedesco P, Johnson TE, Kim SK. An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell, 2008. |
| PubMed ID | 18662544 |
| Short Description | An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. GEO Record: GSE12094 GSE12166 GSE12167 GSE12168 Platform: GPL7065 GPL7066 GPL7067 GPL7068 Download gene-centric, log2 transformed data: WBPaper00032062.ce.mr.csv |
| # of Conditions | 4 |
Full Description
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To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large number of downstream genes that change expression in old age, including ugt-9, col-144, and sod-3. elt-5(RNAi) and elt-6(RNAi) worms have extended longevity, indicating that elt-3, elt-5, and elt-6 play an important functional role in the aging process. These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage. Experimental Details: WBPaper00032062:day_11 WBPaper00032062:day_2 WBPaper00032062:day_5 WBPaper00032062:day_8. |
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