SPELL - Nematode - Dataset Details
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Citation Dillman AR, Macchietto M, Porter CF, Rogers A, Williams B, Antoshechkin I, Lee MM, Goodwin Z, Lu X, Lewis EE, Goodrich-Blair H, Stock SP, Adams BJ, Sternberg PW, Mortazavi A. Comparative genomics of Steinernema reveals deeply conserved gene regulatory networks. Genome Biol, 2015.
PubMed ID 26392177
Short Description Comparative genomics of Steinernema reveals deeply conserved gene regulatory networks.
GEO Record: N.A. Platform: N.A.
Download gene-centric, log2 transformed data: WBPaper00050230.ce.rs.csv
# of Conditions 8
Full Description 1316625150_help BACKGROUND: Parasitism is a major ecological niche for a variety of nematodes. Multiple nematode lineages have specialized as pathogens, including deadly parasites of insects that are used in biological control. We have sequenced and analyzed the draft genomes and transcriptomes of the entomopathogenic nematode Steinernema carpocapsae and four congeners (S. scapterisci, S. monticolum, S. feltiae, and S. glaseri). RESULTS: We used these genomes to establish phylogenetic relationships, explore gene conservation across species, and identify genes uniquely expanded in insect parasites. Protein domain analysis in Steinernema revealed a striking expansion of numerous putative parasitism genes, including certain protease and protease inhibitor families, as well as fatty acid- and retinol-binding proteins. Stage-specific gene expression of some of these expanded families further supports the notion that they are involved in insect parasitism by Steinernema. We show that sets of novel conserved non-coding regulatory motifs are associated with orthologous genes in Steinernema and Caenorhabditis. CONCLUSIONS: We have identified a set of expanded gene families that are likely to be involved in parasitism. We have also identified a set of non-coding motifs associated with groups of orthologous genes in Steinernema and Caenorhabditis involved in neurogenesis and embryonic development that are likely part of conserved protein-DNA relationships shared between these two genera.
Experimental Details:
RNASeq.elegans.WBStrain00000001.WBls:0000003.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019174
RNASeq.elegans.WBStrain00000001.WBls:0000003.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019175
RNASeq.elegans.WBStrain00000001.WBls:0000024.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019176
RNASeq.elegans.WBStrain00000001.WBls:0000024.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019177
RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019178
RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019179
RNASeq.elegans.WBStrain00000001.WBls:0000041.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019180
RNASeq.elegans.WBStrain00000001.WBls:0000041.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019181.
Tags 1316625150_help
Method: RNAseq, Species: Caenorhabditis elegans, Topic: unclassified