SPELL - Nematode

Citation	Heestand BN, Shen Y, Liu W, Magner DB, Storm N, Meharg C, Habermann B, Antebi A. Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet, 2013.
PubMed ID	23935515
Short Description	Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. GEO Record: N.A. Platform: N.A. Download gene-centric, log2 transformed data: WBPaper00044037.ce.rs.csv
# of Conditions	12
Full Description	Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span. Experimental Details: RNASeq.elegans.WBStrain00000001.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494547 RNASeq.elegans.WBStrain00000001.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494548 RNASeq.elegans.WBStrain00000001.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494549 RNASeq.elegans.WBStrain00000029.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494550 RNASeq.elegans.WBStrain00000029.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494551 RNASeq.elegans.WBStrain00000029.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494552 RNASeq.elegans.WBStrain00000031.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494553 RNASeq.elegans.WBStrain00000031.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494554 RNASeq.elegans.WBStrain00000031.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494555 RNASeq.elegans.WBStrain00000030.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494556 RNASeq.elegans.WBStrain00000030.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494557 RNASeq.elegans.WBStrain00000030.WBls:0000063.Hermaphrodite.WBbt:0007833.SRP040269.SRX494558.
Tags	Method: RNAseq, Species: Caenorhabditis elegans, Topic: aging