| Citation | Thomas CG, Li R, Smith HE, Woodruff GC, Oliver B, Haag ES. Simplification and desexualization of gene expression in self-fertile nematodes. Curr Biol, 2012. |
| PubMed ID | 23103191 |
| Short Description | Simplification and desexualization of gene expression in self-fertile nematodes. GEO Record: GSE41367 Platform: GPL13776 GPL13657 GPL13776 GPL16135 GPL16136 GPL16137 GPL16138 GPL16139 GPL16140 GPL16141 Download gene-centric, log2 transformed data: WBPaper00041689.ce.rs.csv |
| # of Conditions | 6 |
Full Description
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Evolutionary transitions between sexual modes could be potent forces in genome evolution. Several Caenorhabditis nematode species have evolved self-fertile hermaphrodites from the obligately outcrossing females of their ancestors. We explored the relationship between sexual mode and global gene expression by comparing two selfing species, C. elegans and C. briggsae, with three phylogenetically informative outcrossing relatives, C. remanei, C. brenneri, and C. japonica. Adult transcriptome assemblies from the selfing species are consistently and strikingly smaller than those of the outcrossing species. Against this background of overall simplification, genes conserved in multiple outcrossing species with strong sex-biased expression are even more likely to be missing from the genomes of the selfing species. In addition, the sexual regulation of remaining transcripts has diverged markedly from the ancestral pattern in both selfing lineages, though in distinct ways. Thus, both the complexity and the sexual specialization of transciptomes are rapidly altered in response to the evolution of self-fertility. These changes may result from the combination of relaxed sexual selection and a recently reported genetic mechanism favoring genome shrinkage in partial selfers. Experimental Details: RNASeq.elegans.WBStrain00000001.WBls:0000041.Hermaphrodite.WBbt:0007833.SRP016006.SRX191947 RNASeq.elegans.WBStrain00000001.WBls:0000041.Hermaphrodite.WBbt:0007833.SRP016006.SRX191948 RNASeq.elegans.WBStrain00000001.WBls:0000041.Hermaphrodite.WBbt:0007833.SRP016006.SRX191949 RNASeq.elegans.WBStrain00000001.WBls:0000041.Male.WBbt:0007833.SRP016006.SRX191950 RNASeq.elegans.WBStrain00000001.WBls:0000041.Male.WBbt:0007833.SRP016006.SRX191951 RNASeq.elegans.WBStrain00000001.WBls:0000041.Male.WBbt:0007833.SRP016006.SRX191952. |
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