| Citation | Vinuela A, Snoek LB, Riksen JA, Kammenga JE. Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. PLoS One, 2011. |
| PubMed ID | 21931806 |
| Short Description | Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. GEO Record: GSE24229 GSE24230 GSE24254 GSE24257 Platform: GPL4038 Download gene-centric, log2 transformed data: WBPaper00040210.ce.mr.csv |
| # of Conditions | 18 |
Full Description
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Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the present study, we investigated genome-wide gene expression profiles in the nematode Caenorhabditis elegans exposed to two OP, chlorpyrifos and diazinon, in single and combined treatments at different temperatures. Our results show that chlorpyrifos and diazinon induced expression of different genes and that temperature affected the response of detoxification genes to the pesticides. The analysis of transcriptional responses to a combination of chlorpyrifos and diazinon shows interactions between toxicants that affect gene expression. Furthermore, our combined analysis of the transcriptional responses to OP at different temperatures suggests that the combination of OP and high temperatures affect detoxification genes and modified the toxic levels of the pesticides. Experimental Details: WBPaper00040210:Control_vs_CPF-(0.5)_Rep1 WBPaper00040210:Control_vs_CPF-(0.5)_Rep2 WBPaper00040210:Control_vs_CPF-(0.5)_Rep3 WBPaper00040210:CPF-(0.5)_vs_Control_Rep1 WBPaper00040210:CPF-(0.5)_vs_Control_Rep2 WBPaper00040210:CPF-(0.5)_vs_Control_Rep3 WBPaper00040210:Control_vs_DZN-(0.5)_Rep1 WBPaper00040210:Control_vs_DZN-(0.5)_Rep2 WBPaper00040210:Control_vs_DZN-(0.5)_Rep3 WBPaper00040210:DZN-(0.5)_vs_Control_Rep1 WBPaper00040210:DZN-(0.5)_vs_Control_Rep2 WBPaper00040210:DZN-(0.5)_vs_Control_Rep3 WBPaper00040210:Control_vs_CPF-(0.5)_DZN-(1)_Rep1 WBPaper00040210:Control_vs_CPF-(0.5)_DZN-(1)_Rep2 WBPaper00040210:Control_vs_CPF-(0.5)_DZN-(1)_Rep3 WBPaper00040210:CPF-(0.5)_DZN-(1)_vs_Control_Rep1 WBPaper00040210:CPF-(0.5)_DZN-(1)_vs_Control_Rep2 WBPaper00040210:CPF-(0.5)_DZN-(1)_vs_Control_Rep3. |
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