| Citation | Vinuela A, Snoek LB, Riksen JA, Kammenga JE. Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans. PLoS One, 2010. |
| PubMed ID | 20808445 |
| Short Description | Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans. GEO Record: GSE16686 GSE16688 GSE16698 GSE16719 Platform: GPL4038 Download gene-centric, log2 transformed data: WBPaper00037113.ce.mr.csv |
| # of Conditions | 18 |
Full Description
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Organophosphorus pesticides (OPs) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Over the past years evidence is mounting that these compounds affect many other processes. Little is known, however, about gene expression responses against OPs in the nematode Caenorhabditis elegans. This is surprising because C. elegans is extensively used as a model species in toxicity studies. To address this question we performed a microarray study in C. elegans which was exposed for 72 hrs to two widely used Ops, chlorpyrifos and diazinon, and a low dose mixture of these two compounds. Our analysis revealed transcriptional responses related to detoxification, stress, innate immunity, and transport and metabolism of lipids in all treatments. We found that for both compounds as well as in the mixture, these processes were regulated by different gene transcripts. Our results illustrate intense, and unexpected crosstalk between gene pathways in response to chlorpyrifos and diazinon in C. elegans. Experimental Details: WBPaper00037113:Control_vs_DZN-(1)_Rep1 WBPaper00037113:Control_vs_DZN-(1)_Rep2 WBPaper00037113:Control_vs_DZN-(1)_Rep3 WBPaper00037113:DZN-(1)_vs_Control_Rep1 WBPaper00037113:DZN-(1)_vs_Control_Rep2 WBPaper00037113:DZN-(1)_vs_Control_Rep3 WBPaper00037113:Control_vs_CPF-(0.5)_Rep1 WBPaper00037113:Control_vs_CPF-(0.5)_Rep2 WBPaper00037113:Control_vs_CPF-(0.5)_Rep3 WBPaper00037113:CPF-(0.5)_vs_Control_Rep1 WBPaper00037113:CPF-(0.5)_vs_Control_Rep2 WBPaper00037113:CPF-(0.5)_vs_Control_Rep3 WBPaper00037113:Control_vs_CPF-(0.5)_DZN-(1)_Rep1 WBPaper00037113:Control_vs_CPF-(0.5)_DZN-(1)_Rep2 WBPaper00037113:Control_vs_CPF-(0.5)_DZN-(1)_Rep3 WBPaper00037113:CPF-(0.5)_DZN-(1)_vs_Control_Rep1 WBPaper00037113:CPF-(0.5)_DZN-(1)_vs_Control_Rep2 WBPaper00037113:CPF-(0.5)_DZN-(1)_vs_Control_Rep3. |
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