SPELL - Nematode

Citation	McCarroll SA, Murphy CT, Zou S, Pletcher SD, Chin CS, Jan YN, Kenyon C, Bargmann CI, Li H. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet, 2004.
PubMed ID	14730301
Short Description	Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. GEO Record: GSE832 GSE946 Platform: GPL576 GPL924 Download gene-centric, log2 transformed data: WBPaper00006365.ce.mr.csv
# of Conditions	14
Full Description	We developed a method for systematically comparing gene expression patterns across organisms using genome-wide comparative analysis of DNA microarray experiments. We identified analogous gene expression programs comprising shared patterns of regulation across orthologous genes. Biological features of these patterns could be identified as highly conserved subpatterns that correspond to Gene Ontology categories. Here, we demonstrate these methods by analyzing a specific biological process, aging, and show that similar analysis can be applied to a range of biological processes. We found that two highly diverged animals, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster, implement a shared adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport. Most of these changes were implemented early in adulthood. Using this approach to search databases of gene expression data, we found conserved transcriptional signatures in larval development, embryogenesis, gametogenesis and mRNA degradation. Experimental Details: WBPaper00006365:Adult_0_hr WBPaper00006365:Adult_8_hr WBPaper00006365:Adult_16_hr WBPaper00006365:Adult_28_hr WBPaper00006365:Adult_52_hr WBPaper00006365:Adult_96_hr WBPaper00006365:Adult_144_hr WBPaper00006365:HeatShock_0_hr WBPaper00006365:HeatShock_2_hr WBPaper00006365:HeatShock_4_hr WBPaper00006365:HeatShock_6_hr WBPaper00006365:HeatShock_8_hr WBPaper00006365:HeatShock_10_hr WBPaper00006365:HeatShock_12_hr.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: aging