| Citation | Viswanathan M, Kim SK, Berdichevsky A, Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell, 2005. |
| PubMed ID | 16256736 |
| Short Description | A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. GEO Record: GSE4402 GSE4093 GSE4094 GSE4095 Platform: GPL3390 GPL3391 Download gene-centric, log2 transformed data: WBPaper00026929.ce.mr.csv |
| # of Conditions | 12 |
Full Description
|
C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases, has been shown to regulate nematode aging via the insulin/IGF pathway transcription factor daf-16. Treatment of C. elegans with the small molecule resveratrol, however, extends life span in a manner fully dependent upon sir-2.1, but independent of daf-16. Microarray analysis of worms treated with resveratrol demonstrates the transcriptional induction of a family of genes encoding prion-like glutamine/asparagine-rich proteins involved in endoplasmic reticulum (ER) stress response to unfolded proteins. RNA interference of abu-11, a member of this ER stress gene family, abolishes resveratrol-mediated life span extension, and overexpression of abu-11 extends the life span of transgenic animals. Furthermore, SIR-2.1 normally represses transcription of abu-11 and other ER stress gene family members, indicating that resveratrol extends life span by inhibiting sir-2.1-mediated repression of ER stress genes. Our findings demonstrate that abu-11 and other members of its ER stress gene family are positive determinants of C. elegans life span. Experimental Details: WBPaper00026929:Resveratrol_daf-16_Rep1 WBPaper00026929:Resveratrol_daf-16_Rep2 WBPaper00026929:Resveratrol_daf-16_Rep3 WBPaper00026929:Resveratrol_daf-16_Rep4 WBPaper00026929:Resveratrol_N2_Rep1 WBPaper00026929:Resveratrol_N2_Rep2 WBPaper00026929:Resveratrol_N2_Rep3 WBPaper00026929:Resveratrol_N2_Rep4 WBPaper00026929:sir-2.1_overexpression_Rep1 WBPaper00026929:sir-2.1_overexpression_Rep2 WBPaper00026929:sir-2.1_overexpression_Rep3 WBPaper00026929:sir-2.1_overexpression_Rep4. |
|
Tags
|
Contact: help (at) wormbase.org
