| Citation | Shapira M, Hamlin BJ, Rong J, Chen K, Ronen M, Tan MW. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A, 2006. |
| PubMed ID | 16968778 |
| Short Description | A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. GEO Record: GSE5584 Platform: GPL4206 GPL4207 GPL4208 Download gene-centric, log2 transformed data: WBPaper00028482.ce.mr.csv |
| # of Conditions | 18 |
Full Description
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Innate immunity is an ancient and conserved defense mechanism. Although host responses toward various pathogens have been delineated, how these responses are orchestrated in a whole animal is less understood. Through an unbiased genome-wide study performed in Caenorhabditis elegans, we identified a conserved function for endodermal GATA transcription factors in regulating local epithelial innate immune responses. Gene expression and functional RNAi-based analyses identified the tissue-specific GATA transcription factor ELT-2 as a major regulator of an early intestinal protective response to infection with the human bacterial pathogen Pseudomonas aeruginosa. In the adult worm, ELT-2 is required specifically for infection responses and survival on pathogen but makes no significant contribution to gene expression associated with intestinal maintenance or to resistance to cadmium, heat, and oxidative stress. We further demonstrate that this function is conserved, because the human endodermal transcription factor GATA6 has a protective function in lung epithelial cells exposed to P. aeruginosa. These findings expand the repertoire of innate immunity mechanisms and illuminate a yet-unknown function of endodermal GATA proteins. Experimental Details: WBPaper00028482:op50_12hrs_4/24_n2 WBPaper00028482:op50_12hr_4/25_n2 WBPaper00028482:op50_12hr_4/26_n2 WBPaper00028482:op50_4/21_n2_24hr WBPaper00028482:op50_4/22_n2_24hr WBPaper00028482:op50_5/07_N2_4hr WBPaper00028482:op50_5/29_new_N2_4hrs WBPaper00028482:op50_6/29_N2_4hrs WBPaper00028482:op50_n2_11/19_24hr WBPaper00028482:pa14_12hrs_4/24_n2 WBPaper00028482:pa14_12hr_4/25_n2 WBPaper00028482:pa14_12hr_4/26_n2 WBPaper00028482:pa14_4/21_n2_24hrs WBPaper00028482:pa14_4/22_n2_24hrs WBPaper00028482:pa14_4/23_n2_24hrs WBPaper00028482:pa14_5/29_n2_4hr WBPaper00028482:pa14_5/7_n2_4hr WBPaper00028482:pa14_629new_4hr. |
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