SPELL - Nematode

Citation	Denver DR, Morris K, Streelman JT, Kim SK, Lynch M, Thomas WK. The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans. Nat Genet, 2005.
PubMed ID	15852004
Short Description	The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans. GEO Record: GSE4123 Platform: GPL2646 GPL2766 GPL3096 GPL3097 GPL3098 GPL3178 GPL3399 Download gene-centric, log2 transformed data: WBPaper00025099.ce.mr.csv
# of Conditions	49
Full Description	The evolutionary importance of gene-expression divergence is unclear: some studies suggest that it is an important mechanism for evolution by natural selection, whereas others claim that most between-species regulatory changes are neutral or nearly neutral. We examined global transcriptional divergence patterns in a set of Caenorhabditis elegans mutation-accumulation lines and natural isolate lines to provide insights into the evolutionary importance of transcriptional variation and to discriminate between the forces of mutation and natural selection in shaping the evolution of gene expression. We detected the effects of selection on transcriptional divergence patterns and characterized them with respect to coexpressed gene sets, chromosomal clustering of expression changes and functional gene categories. We directly compared observed transcriptional variation patterns in the mutation-accumulation and natural isolate lines to a neutral model of transcriptome evolution to show that strong stabilizing selection dominates the evolution of transcriptional change for thousands of C. elegans expressed sequences. Experimental Details: WBPaper00025099:N2-II_starting_line_vs_MA96-II_no_selection WBPaper00025099:N2-I_starting_line_vs_PB306-I_with_selection WBPaper00025099:N2-III_starting_line_vs_MA59-III_no_selection WBPaper00025099:N2-II_starting_line_vs_MA59-II_no_selection WBPaper00025099:MA41-4_A_no_selection_vs_MA24-4_B_no_selection WBPaper00025099:MA41-3_A_no_selection_vs_MA24-3_B_no_selection WBPaper00025099:CB4856-3_A_vs_AB1-3_B WBPaper00025099:CB4856-4_A_vs_AB1-4_B WBPaper00025099:N2-I_starting_line_vs_MA96-I_no_selection WBPaper00025099:N2_vs_MA24_rep1 WBPaper00025099:N2_vs_MA24_rep2 WBPaper00025099:N2_vs_MA24_rep3 WBPaper00025099:N2_vs_MA99_rep1 WBPaper00025099:MA24-3_A_vs_N2-3_B WBPaper00025099:N2-II_starting_line_vs_PB306-II_with_selection WBPaper00025099:N2-III_starting_line_vs_PB306-III_with_selection WBPaper00025099:MA24-2_B_no_selection_vs_MA41-2_A_no_selection WBPaper00025099:MA24-1_B_no_selection_vs_MA41-1_A_no_selection WBPaper00025099:N2-I_starting_line_vs_MA59-I_no_selection WBPaper00025099:PB303-3_A_vs_N2-3_B WBPaper00025099:AB1-3_A_vs_PB306-3_B WBPaper00025099:MA83-2_B_vs_MA99-2_A WBPaper00025099:AB1-1_B_vs_CB4856-1_A WBPaper00025099:MA83-1_B_vs_MA99-1_A WBPaper00025099:CB4856-2_B_vs_N2-2_A WBPaper00025099:MA99-4_A_vs_MA83-4_B WBPaper00025099:MA99-3_A_vs_MA83-3_B WBPaper00025099:N2-3_A_vs_CB4856-3_B WBPaper00025099:PB303-4_A_vs_N2-4_B WBPaper00025099:N2_vs_MA99_rep2 WBPaper00025099:MA41-1_B_vs_MA83-1_A WBPaper00025099:N2-4_A_vs_CB4856-4_B WBPaper00025099:PB303-1_B_vs_PB306-1_A WBPaper00025099:MA99_vs_N2_rep1 WBPaper00025099:MA83-4_A_vs_MA41-4_B WBPaper00025099:AB1-2_B_vs_CB4856-2_A WBPaper00025099:PB303-2_B_vs_PB306-2_A WBPaper00025099:MA99_vs_N2_rep2 WBPaper00025099:MA83-3_A_vs_MA41-3_B WBPaper00025099:PB306-4_A_vs_PB303-4_B WBPaper00025099:N2_vs_PB303 WBPaper00025099:N2-1_B_vs_PB303-1_A WBPaper00025099:PB306-1_B_vs_AB1-1_A WBPaper00025099:AB1_vs_PB306-1 WBPaper00025099:MA24-4_A_vs_N2-4_B WBPaper00025099:PB306-2_B_vs_AB1-2_A WBPaper00025099:PB303_vs_PB306-2 WBPaper00025099:CB4856_vs_N2 WBPaper00025099:MA41_vs_MA83.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: natural variant