| Citation | Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank J. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat Immunol, 2004. |
| PubMed ID | 15048112 |
| Short Description | TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. GEO Record: N.A. Platform: N.A. Download gene-centric, log2 transformed data: WBPaper00006488.ce.mr.csv |
| # of Conditions | 16 |
Full Description
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Both plants and animals respond to infection by synthesizing compounds that directly inhibit or kill invading pathogens. We report here the identification of infection-inducible antimicrobial peptides in Caenorhabditis elegans. Expression of two of these peptides, NLP-29 and NLP-31, was differentially regulated by fungal and bacterial infection and was controlled in part by tir-1, which encodes an ortholog of SARM, a Toll-interleukin 1 receptor (TIR) domain protein. Inactivation of tir-1 by RNA interference caused increased susceptibility to infection. We identify protein partners for TIR-1 and show that the small GTPase Rab1 and the f subunit of ATP synthase participate specifically in the control of antimicrobial peptide gene expression. As the activity of tir-1 was independent of the single nematode Toll-like receptor, TIR-1 may represent a component of a previously uncharacterized, but conserved, innate immune Experimental Details: WBPaper00006488:fer-15(b26ts)_12h_DConiospora_rep3 WBPaper00006488:fer-15(b26ts)_12h_DConiospora_rep2 WBPaper00006488:fer-15(b26ts)_12h_DConiospora_rep1 WBPaper00006488:fer-15(b26ts)_12h_DConiospora_rep4 WBPaper00006488:fer-15(b26ts)_12h_control_rep1 WBPaper00006488:fer-15(b26ts)_12h_control_rep2 WBPaper00006488:fer-15(b26ts)_12h_control_rep4 WBPaper00006488:fer-15(b26ts)_12h_control_rep3 WBPaper00006488:fer-15(b26ts)_24h_DConiospora_rep3 WBPaper00006488:fer-15(b26ts)_24h_DConiospora_rep2 WBPaper00006488:fer-15(b26ts)_24h_DConiospora_rep4 WBPaper00006488:fer-15(b26ts)_24h_control_rep1 WBPaper00006488:fer-15(b26ts)_24h_control_rep2 WBPaper00006488:fer-15(b26ts)_24h_control_rep4 WBPaper00006488:fer-15(b26ts)_24h_control_rep3 WBPaper00006488:fer-15(b26ts)_24h_DConiospora_rep1. |
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