| Citation | Roy PJ, Stuart JM, Lund J, Kim SK. Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. Nature, 2002. |
| PubMed ID | 12214599 |
| Short Description | Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. GEO Record: GSE2971 Platform: GPL2653 Download gene-centric, log2 transformed data: WBPaper00005428.ce.mr.csv |
| # of Conditions | 6 |
Full Description
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Chromosomes are divided into domains of open chromatin, where genes have the potential to be expressed, and domains of closed chromatin, where genes are not expressed1. Classic examples of open chromatin domains include puffs on polytene chromosomes in Drosophila and extended loops from lampbrush chromosomes2,3. If multiple genes were typically expressed together from a single open chromatin domain, the position of co-expressed genes along the chromosomes would appear clustered. To investigate whether co-expressed genes are clustered, we examined the chromosomal positions of the genes expressed in muscle of Caenorhabditis elegans at the first larval stage. Here we show that co-expressed genes in C. elegans are clustered in groups of 25 along the chromosomes, suggesting that expression from a chromatin domain can extend over several genes. These observations reveal a higher-order organization of the structure of the genome, in which the order of genes along the chromosome is correlated with their expression in specific tissues. Experimental Details: WBPaper00005428:myo-3p-IP_vs_totalRNA_Rep2 WBPaper00005428:myo-3p-IP_vs_totalRNA_Rep3 WBPaper00005428:myo-3p-IP_vs_totalRNA_Rep4 WBPaper00005428:myo-3p-IP_vs_totalRNA_Rep5 WBPaper00005428:myo-3p-IP_vs_totalRNA_Rep6 WBPaper00005428:myo-3p-IP_vs_totalRNA_Rep1. |
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