| Citation | van Sluijs L, Liu J, Schrama M, van Hamond S, Vromans SPJM, Scholten MH, Zibrat N, Riksen JAG, Pijlman GP, Sterken MG, Kammenga JE. Virus infection modulates male sexual behavior in Caenorhabditis elegans. Mol Ecol, 2021. |
| PubMed ID | 34534386 |
| Short Description | Virus infection modulates male sexual behavior in Caenorhabditis elegans. GEO Record: N.A. Platform: N.A. Download gene-centric, log2 transformed data: WBPaper00061936.ce.mr.csv |
| # of Conditions | 32 |
Full Description
|
Mating dynamics follow from natural selection on mate choice and individuals maximizing their reproductive success. Mate discrimination reveals itself by a plethora of behaviors and morphological characteristics, each of which can be affected by pathogens. A key question is how pathogens affect mate choice and outcrossing behavior. Here we investigated the effect of Orsay virus on the mating dynamics of the androdiecious (male and hermaphrodite) nematode Caenorhabditis elegans. We tested genetically distinct strains and found that viral susceptibility differed between sexes in a genotype-dependent manner with males of reference strain N2 being more resistant than hermaphrodites. Males displayed a constitutively higher expression of Intracellular Pathogen Response (IPR) genes, whereas the antiviral RNAi response did not have increased activity in males. Subsequent monitoring of sex ratios over ten generations revealed that viral presence can change mating dynamics in isogenic populations. Sexual attraction assays showed that males preferred mating with uninfected rather than infected hermaphrodites. Together our results illustrate for the first time that viral infection can significantly affect male mating choice and suggest altered mating dynamics as a novel cause benefitting outcrossing under pathogenic stress conditions in C. elegans. Experimental Details: WBPaper00061936:male_noInfection_rep1 WBPaper00061936:male_noInfection_rep12 WBPaper00061936:hermaphrodite_noInfection_rep14 WBPaper00061936:hermaphrodite_noInfection_rep15 WBPaper00061936:hermaphrodite_noInfection_rep16 WBPaper00061936:hermaphrodite_noInfection_rep18 WBPaper00061936:hermaphrodite_noInfection_rep2 WBPaper00061936:male_noInfection_rep28 WBPaper00061936:male_noInfection_rep3 WBPaper00061936:hermaphrodite_noInfection_rep31 WBPaper00061936:male_noInfection_rep32 WBPaper00061936:hermaphrodite_noInfection_rep4 WBPaper00061936:male_noInfection_rep5 WBPaper00061936:hermaphrodite_noInfection_rep6 WBPaper00061936:male_noInfection_rep7 WBPaper00061936:male_noInfection_rep9 WBPaper00061936:hermaphrodite_OrsayVirus_rep10 WBPaper00061936:male_OrsayVirus_rep11 WBPaper00061936:hermaphrodite_OrsayVirus_rep13 WBPaper00061936:male_OrsayVirus_rep17 WBPaper00061936:hermaphrodite_OrsayVirus_rep19 WBPaper00061936:male_OrsayVirus_rep20 WBPaper00061936:hermaphrodite_OrsayVirus_rep21 WBPaper00061936:male_OrsayVirus_rep22 WBPaper00061936:hermaphrodite_OrsayVirus_rep23 WBPaper00061936:male_OrsayVirus_rep24 WBPaper00061936:hermaphrodite_OrsayVirus_rep25 WBPaper00061936:male_OrsayVirus_rep26 WBPaper00061936:hermaphrodite_OrsayVirus_rep27 WBPaper00061936:male_OrsayVirus_rep29 WBPaper00061936:hermaphrodite_OrsayVirus_rep30 WBPaper00061936:male_OrsayVirus_rep8. |
|
Tags
|
Contact: help (at) wormbase.org
