| Citation | Heimbucher T, Hog J, Gupta P, Murphy CT. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Nat Commun, 2020. |
| PubMed ID | 33009389 |
| Short Description | PQM-1 controls hypoxic survival via regulation of lipid metabolism. GEO Record: GSE139562 Platform: GPL10094 Download gene-centric, log2 transformed data: WBPaper00060399.ce.mr.csv |
| # of Conditions | 24 |
Full Description
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Animals have evolved responses to low oxygen conditions to ensure their survival. Here, we have identified the C. elegans zinc finger transcription factor PQM-1 as a regulator of the hypoxic stress response. PQM-1 is required for the longevity of insulin signaling mutants, but surprisingly, loss of PQM-1 increases survival under hypoxic conditions. PQM-1 functions as a metabolic regulator by controlling oxygen consumption rates, suppressing hypoxic glycogen levels, and inhibiting the expression of the sorbitol dehydrogenase-1 SODH-1, a crucial sugar metabolism enzyme. PQM-1 promotes hypoxic fat metabolism by maintaining the expression of the stearoyl-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis. PQM-1 activity positively regulates fat transport to developing oocytes through vitellogenins under hypoxic conditions, thereby increasing survival rates of arrested progeny during hypoxia. Thus, while pqm-1 mutants increase survival of mothers, ultimately this loss is detrimental to progeny survival. Our data support a model in which PQM-1 controls a trade-off between lipid metabolic activity in the mother and her progeny to promote the survival of the species under hypoxic conditions. Experimental Details: WBPaper00060399:N2_CoCl2_6hr_vs_N2_control_6hr_rep1 WBPaper00060399:N2_CoCl2_6hr_vs_N2_control_6hr_rep2 WBPaper00060399:N2_CoCl2_6hr_vs_N2_control_6hr_rep3 WBPaper00060399:pqm-1(ok485)_CoCl2_6hr_vs_pqm-1(ok485)_control_6hr_rep1b WBPaper00060399:pqm-1(ok485)_CoCl2_6hr_vs_pqm-1(ok485)_control_6hr_rep2 WBPaper00060399:pqm-1(ok485)_CoCl2_6hr_vs_pqm-1(ok485)_control_6hr_rep3 WBPaper00060399:pqm-1(ok485)_control_6hr_vs_N2_control_6hr_rep1b WBPaper00060399:pqm-1(ok485)_control_6hr_vs_N2_control_6hr_rep2 WBPaper00060399:pqm-1(ok485)_control_6hr_vs_N2_control_6hr_rep3 WBPaper00060399:pqm-1(ok485)_CoCl2_6hr_vs_N2_CoCl2_6hr_rep1 WBPaper00060399:pqm-1(ok485)_CoCl2_6hr_vs_N2_CoCl2_6hr_rep2 WBPaper00060399:pqm-1(ok485)_CoCl2_6hr_vs_N2_CoCl2_6hr_rep3 WBPaper00060399:N2_CoCl2_20hr_vs_N2_control_20hr_rep1b WBPaper00060399:N2_CoCl2_20hr_vs_N2_control_20hr_rep2 WBPaper00060399:N2_CoCl2_20hr_vs_N2_control_20hr_rep3 WBPaper00060399:pqm-1(ok485)_CoCl2_20hr_vs_pqm-1(ok485)_control_20hr_rep1 WBPaper00060399:pqm-1(ok485)_CoCl2_20hr_vs_pqm-1(ok485)_control_20hr_rep2 WBPaper00060399:pqm-1(ok485)_CoCl2_20hr_vs_pqm-1(ok485)_control_20hr_rep3 WBPaper00060399:pqm-1(ok485)_control_20hr_vs_N2_control_20hr_rep1 WBPaper00060399:pqm-1(ok485)_control_20hr_vs_N2_control_20hr_rep2 WBPaper00060399:pqm-1(ok485)_control_20hr_vs_N2_control_20hr_rep3 WBPaper00060399:pqm-1(ok485)_CoCl2_20hr_vs_N2_CoCl2_20hr_rep1 WBPaper00060399:pqm-1(ok485)_CoCl2_20hr_vs_N2_CoCl2_20hr_rep2 WBPaper00060399:pqm-1(ok485)_CoCl2_20hr_vs_N2_CoCl2_20hr_rep3. |
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