SPELL - Nematode - Dataset Details
New Search

Dataset Listing

Show Expression Levels

Download Expression Data

About the Website

SPELL Version 2.0.3

Citation Sterken MG, van Wijk MH, Quamme EC, Riksen JAG, Carnell L, Mathies LD, Davies AG, Kammenga JE, Bettinger JC. Transcriptional analysis of the response of C. elegans to ethanol exposure. Sci Rep, 2021.
PubMed ID 34040055
Short Description Transcriptional analysis of the response of C. elegans to ethanol exposure.
GEO Record: N.A. Platform: N.A.
Download gene-centric, log2 transformed data: WBPaper00061443.ce.mr.csv
# of Conditions 40
Full Description 1316625150_help Ethanol-induced transcriptional changes underlie important physiological responses to ethanol that are likely to contribute to the addictive properties of the drug. We examined the transcriptional responses of Caenorhabditis elegans across a timecourse of ethanol exposure, between 30 min and 8 h, to determine what genes and genetic pathways are regulated in response to ethanol in this model. We found that short exposures to ethanol (up to 2 h) induced expression of metabolic enzymes involved in metabolizing ethanol and retinol, while longer exposure (8 h) had much more profound effects on the transcriptome. Several genes that are known to be involved in the physiological response to ethanol, including direct ethanol targets, were regulated at 8 h of exposure. This longer exposure to ethanol also resulted in the regulation of genes involved in cilia function, which is consistent with an important role for the effects of ethanol on cilia in the deleterious effects of chronic ethanol consumption in humans. Finally, we found that food deprivation for an 8-h period induced gene expression changes that were somewhat ameliorated by the presence of ethanol, supporting previous observations that worms can use ethanol as a calorie source.
Experimental Details:
WBPaper00061443:0.4mM-ethanol_120min_Sample1
WBPaper00061443:0.4mM-ethanol_480min_Sample2
WBPaper00061443:0.4mM-ethanol_120min_Sample3
WBPaper00061443:0.4mM-ethanol_0min_Sample4
WBPaper00061443:0.4mM-ethanol_60min_Sample5
WBPaper00061443:0.4mM-ethanol_30min_Sample6
WBPaper00061443:0.4mM-ethanol_30min_Sample7
WBPaper00061443:0.4mM-ethanol_60min_Sample8
WBPaper00061443:control_0min_Sample9
WBPaper00061443:control_0min_Sample10
WBPaper00061443:control_480min_Sample11
WBPaper00061443:control_30min_Sample12
WBPaper00061443:control_60min_Sample13
WBPaper00061443:0.4mM-ethanol_480min_Sample14
WBPaper00061443:control_480min_Sample15
WBPaper00061443:0.4mM-ethanol_0min_Sample16
WBPaper00061443:control_60min_Sample17
WBPaper00061443:control_120min_Sample18
WBPaper00061443:control_30min_Sample19
WBPaper00061443:control_120min_Sample20
WBPaper00061443:0.4mM-ethanol_480min_Sample21
WBPaper00061443:0.4mM-ethanol_60min_Sample22
WBPaper00061443:control_60min_Sample23
WBPaper00061443:0.4mM-ethanol_30min_Sample24
WBPaper00061443:0.4mM-ethanol_480min_Sample25
WBPaper00061443:control_120min_Sample26
WBPaper00061443:0.4mM-ethanol_0min_Sample27
WBPaper00061443:control_60min_Sample28
WBPaper00061443:control_120min_Sample29
WBPaper00061443:0.4mM-ethanol_30min_Sample30
WBPaper00061443:control_0min_Sample31
WBPaper00061443:0.4mM-ethanol_60min_Sample32
WBPaper00061443:0.4mM-ethanol_0min_Sample33
WBPaper00061443:control_480min_Sample34
WBPaper00061443:0.4mM-ethanol_120min_Sample35
WBPaper00061443:0.4mM-ethanol_120min_Sample36
WBPaper00061443:control_30min_Sample37
WBPaper00061443:control_0min_Sample38
WBPaper00061443:control_30min_Sample39
WBPaper00061443:control_480min_Sample40.
Tags 1316625150_help
Method: microarray, Species: Caenorhabditis elegans