| Citation | Sonoda S, Ohta A, Maruo A, Ujisawa T, Kuhara A. Sperm Affects Head Sensory Neuron in Temperature Tolerance of Caenorhabditis elegans. Cell Rep, 2016. |
| PubMed ID | 27320929 |
| Short Description | Sperm Affects Head Sensory Neuron in Temperature Tolerance of Caenorhabditis elegans. GEO Record: GSE81409 Platform: GPL10094 Download gene-centric, log2 transformed data: WBPaper00049736.ce.mr.csv |
| # of Conditions | 12 |
Full Description
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Tolerance to environmental temperature change is essential for the survival and proliferation of animals. The process is controlled by various body tissues, but the orchestration of activity within the tissue network has not been elucidated in detail. Here, we show that sperm affects the activity of temperature-sensing neurons (ASJ) that control cold tolerance in Caenorhabditis elegans. Genetic impairment of sperm caused abnormal cold tolerance, which was unexpectedly restored by impairment of temperature signaling in ASJ neurons. Calcium imaging revealed that ASJ neuronal activity in response to temperature was decreased in sperm mutant gsp-4 with impaired protein phosphatase 1 and rescued by expressing gsp-4 in sperm. Genetic analysis revealed a feedback network in which ASJ neuronal activity regulates the intestine through insulin and a steroid hormone, which then affects sperm and, in turn, controls ASJ neuronal activity. Thus, we propose that feedback between sperm and a sensory neuron mediating temperature tolerance. Experimental Details: WBPaper00049736:N2_15deg_repA WBPaper00049736:N2_15deg-then-25deg(3hr)_repA WBPaper00049736:N2_15deg-then-25deg(12hr)_repA WBPaper00049736:daf-2(e1370)_15deg-then-25deg(12hr)_repA WBPaper00049736:N2_15deg_repB WBPaper00049736:N2_15deg-then-25deg(3hr)_repB WBPaper00049736:N2_15deg-then-25deg(12hr)_repB WBPaper00049736:daf-2(e1370)_15deg-then-25deg(12hr)_repB WBPaper00049736:N2_15deg_rep1 WBPaper00049736:N2_15deg-then-25deg(3hr)_rep1 WBPaper00049736:N2_15deg-then-25deg(12hr)_rep1 WBPaper00049736:daf-2(e1370)_15deg-then-25deg(12hr)_rep1. |
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