| Citation | Schott D, Yanai I, Hunter CP. Natural RNA interference directs a heritable response to the environment. Sci Rep, 2014. |
| PubMed ID | 25552271 |
| Short Description | Natural RNA interference directs a heritable response to the environment. GEO Record: GSE30666 Platform: GPL13914 Download gene-centric, log2 transformed data: WBPaper00046212.ce.mr.csv |
| # of Conditions | 24 |
Full Description
|
RNA interference can induce heritable gene silencing, but it remains unexplored whether similar mechanisms play a general role in responses to cues that occur in the wild. We show that transient, mild heat stress in the nematode Caenorhabditis elegans results in changes in messenger RNA levels that last for more than one generation. The affected transcripts are enriched for genes targeted by germline siRNAs downstream of the piRNA pathway, and worms defective for germline RNAi are defective for these heritable effects. Our results demonstrate that a specific siRNA pathway transmits information about variable environmental conditions between generations. Experimental Details: WBPaper00046212:N2_20C-G2_rep1 WBPaper00046212:N2_20C-G2_rep2 WBPaper00046212:N2_20C-G2_rep3 WBPaper00046212:N2_25C-G2_rep1 WBPaper00046212:N2_25C-G2_rep2 WBPaper00046212:N2_25C-G2_rep3 WBPaper00046212:HC445_20C-G2_rep1 WBPaper00046212:HC445_20C-G2_rep2 WBPaper00046212:HC445_20C-G2_rep3 WBPaper00046212:HC445_25C-G2_rep1 WBPaper00046212:HC445_25C-G2_rep2 WBPaper00046212:HC445_25C-G2_rep3 WBPaper00046212:N2_20C-G2-20C-G3_rep1 WBPaper00046212:N2_20C-G2-20C-G3_rep2 WBPaper00046212:N2_20C-G2-20C-G3_rep3 WBPaper00046212:N2_25C-G2-20C-G3_rep1 WBPaper00046212:N2_25C-G2-20C-G3_rep2 WBPaper00046212:N2_25C-G2-20C-G3_rep3 WBPaper00046212:HC445_20C-G2-20C-G3_rep1 WBPaper00046212:HC445_20C-G2-20C-G3_rep2 WBPaper00046212:HC445_20C-G2-20C-G3_rep3 WBPaper00046212:HC445_25C-G2-20C-G3_rep1 WBPaper00046212:HC445_25C-G2-20C-G3_rep2 WBPaper00046212:HC445_25C-G2-20C-G3_rep3. |
|
Tags
|
Contact: help (at) wormbase.org
