| Citation | Head B, Aballay A. Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2. PLoS Genet, 2014. |
| PubMed ID | 25340560 |
| Short Description | Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2. GEO Record: GSE54212 Platform: GPL11346 Download gene-centric, log2 transformed data: WBPaper00045918.ce.mr.csv |
| # of Conditions | 14 |
Full Description
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The mechanisms involved in the recognition of microbial pathogens and activation of the immune system have been extensively studied. However, the mechanisms involved in the recovery phase of an infection are incompletely characterized at both the cellular and physiological levels. Here, we establish a Caenorhabditis elegans-Salmonella enterica model of acute infection and antibiotic treatment for studying biological changes during the resolution phase of an infection. Using whole genome expression profiles of acutely infected animals, we found that genes that are markers of innate immunity are down-regulated upon recovery, while genes involved in xenobiotic detoxification, redox regulation, and cellular homeostasis are up-regulated. In silico analyses demonstrated that genes altered during recovery from infection were transcriptionally regulated by conserved transcription factors, including GATA/ELT-2, FOXO/DAF-16, and Nrf/SKN-1. Finally, we found that recovery from an acute bacterial infection is dependent on ELT-2 activity. Experimental Details: WBPaper00045918:fer-1_36h_E.coli-OP50_rep1 WBPaper00045918:fer-1_36h_E.coli-OP50_rep2 WBPaper00045918:fer-1_36h_S.enterica-SL1344_rep1 WBPaper00045918:fer-1_36h_S.enterica-SL1344_rep2 WBPaper00045918:fer-1_72h_S.enterica-SL1344_rep1 WBPaper00045918:fer-1_72h_S.enterica-SL1344_rep2 WBPaper00045918:fer-1_96h_S.enterica-SL1344_rep1 WBPaper00045918:fer-1_96h_S.enterica-SL1344_rep2 WBPaper00045918:fer-1_120h_S.enterica-SL1344_rep1 WBPaper00045918:fer-1_120h_S.enterica-SL1344_rep2 WBPaper00045918:fer-1_96h_E.coli-HT115+Tet_rep1 WBPaper00045918:fer-1_96h_E.coli-HT115+Tet_rep2 WBPaper00045918:fer-1_120h_E.coli-HT115+Tet_rep1 WBPaper00045918:fer-1_120h_E.coli-HT115+Tet_rep2. |
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