| Citation | Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell, 2012. |
| PubMed ID | 22560298 |
| Short Description | Developmental milestones punctuate gene expression in the Caenorhabditis embryo. GEO Record: GSE31422 Platform: GPL14144 Download gene-centric, log2 transformed data: WBPaper00041190.cbn.mr.csv |
| # of Conditions | 30 |
Full Description
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A fundamental question in developmental biology relates to the connection between morphological stages and their underlying molecular activity. Here we demonstrate that, at the molecular level, embryonic development in five Caenorhabditis species proceeds through two distinct milestones in which the transcriptome is resistant to differences in species-specific developmental timings. By comparing the complete protein-coding transcriptomes of individually timed embryos across ten morphological markers, we found that developmental milestones can be characterized by their expression dynamics and activation of key developmental regulators. This approach led us to discover the nematode phylotypic stage and to show that in chordates and arthropods it is represented as two distinct stages, suggesting that animal body plans might evolve by uncoupling and elaboration on formerly synchronous processes. Experimental Details: WBPaper00041190:C.brenneri_rep1_stage1 WBPaper00041190:C.brenneri_rep1_stage2 WBPaper00041190:C.brenneri_rep1_stage3 WBPaper00041190:C.brenneri_rep1_stage4 WBPaper00041190:C.brenneri_rep1_stage5 WBPaper00041190:C.brenneri_rep1_stage6 WBPaper00041190:C.brenneri_rep1_stage7 WBPaper00041190:C.brenneri_rep1_stage8 WBPaper00041190:C.brenneri_rep1_stage9 WBPaper00041190:C.brenneri_rep1_stage10 WBPaper00041190:C.brenneri_rep2_stage1 WBPaper00041190:C.brenneri_rep2_stage2 WBPaper00041190:C.brenneri_rep2_stage3 WBPaper00041190:C.brenneri_rep2_stage4 WBPaper00041190:C.brenneri_rep2_stage5 WBPaper00041190:C.brenneri_rep2_stage6 WBPaper00041190:C.brenneri_rep2_stage7 WBPaper00041190:C.brenneri_rep2_stage8 WBPaper00041190:C.brenneri_rep2_stage9 WBPaper00041190:C.brenneri_rep2_stage10 WBPaper00041190:C.brenneri_rep3_stage1 WBPaper00041190:C.brenneri_rep3_stage2 WBPaper00041190:C.brenneri_rep3_stage3 WBPaper00041190:C.brenneri_rep3_stage4 WBPaper00041190:C.brenneri_rep3_stage5 WBPaper00041190:C.brenneri_rep3_stage6 WBPaper00041190:C.brenneri_rep3_stage7 WBPaper00041190:C.brenneri_rep3_stage8 WBPaper00041190:C.brenneri_rep3_stage9 WBPaper00041190:C.brenneri_rep3_stage10. |
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