| Citation | Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV. Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. Virulence, 2018. |
| PubMed ID | 29532717 |
| Short Description | Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. GEO Record: GSE95510 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00053827.ce.mr.csv |
| # of Conditions | 9 |
Full Description
|
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron from the host prior to its eventual exit. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions. Experimental Details: WBPaper00053827:glp-4_NGM_repA WBPaper00053827:glp-4_NGM_repB WBPaper00053827:glp-4_NGM_repC WBPaper00053827:glp-4_Basal_repA WBPaper00053827:glp-4_Basal_repB WBPaper00053827:glp-4_Basal_repC WBPaper00053827:glp-4_PVD_repA WBPaper00053827:glp-4_PVD_repB WBPaper00053827:glp-4_PVD_repC. |
|
Tags
|
Contact: help (at) wormbase.org
