| Citation | Navarro-Herrera D, Aranaz P, Eder-Azanza L, Zabala M, Hurtado C, Romo-Hualde A, Martinez JA, Gonzalez-Navarro CJ, Vizmanos JL. Dihomo-gamma-linolenic acid induces fat loss in C. elegans in an omega-3-independent manner by promoting peroxisomal fatty acid -oxidation. Food Funct, 2018. |
| PubMed ID | 29465730 |
| Short Description | Dihomo-gamma-linolenic acid induces fat loss in C. elegans in an omega-3-independent manner by promoting peroxisomal fatty acid -oxidation. GEO Record: GSE102802 Platform: GPL19230 Download gene-centric, log2 transformed data: WBPaper00053736.ce.mr.csv |
| # of Conditions | 12 |
Full Description
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Bioactive compounds, including some fatty acids (FAs), can induce beneficial effects on body fat-content and metabolism. In this work, we have used C. elegans as a model to examine the effects of several FAs on body fat accumulation. Both omega-3 and omega-6 fatty acids induced a reduction of fat content in C. elegans, with linoleic, gamma-linolenic and dihomo-gamma-linolenic acids being the most effective ones. These three FAs are sequential metabolites especially in omega-6 PUFA synthesis pathway and the effects seem to be primarily due to dihomo-gamma-linolenic acid, and independent of its transformation into omega-3 or arachidonic acid. Gene expression analyses suggest that peroxisomal beta oxidation is the main mechanism involved in the observed effect. These results point out the importance of further analysis of the activity of these omega-6 FAs, due to their potential application in obesity and related diseases. Experimental Details: WBPaper00053736:NGMcontrol_rep1 WBPaper00053736:NGMcontrol_rep2 WBPaper00053736:NGMcontrol_rep3 WBPaper00053736:LNA_rep1 WBPaper00053736:LNA_rep2 WBPaper00053736:LNA_rep3 WBPaper00053736:GLA_rep1 WBPaper00053736:GLA_rep2 WBPaper00053736:GLA_rep3 WBPaper00053736:DGLA_rep1 WBPaper00053736:DGLA_rep2 WBPaper00053736:DGLA_rep3. |
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