| Citation | Gaudet J, Mango SE. Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Science, 2002. |
| PubMed ID | 11823633 |
| Short Description | Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. GEO Record: GSE3681 Platform: GPL3177 GPL3178 Download gene-centric, log2 transformed data: WBPaper00005056.ce.mr.csv |
| # of Conditions | 1 |
Full Description
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The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R=A/G, K=T/G, Y=T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes. Experimental Details: [cgc5056]:par-1_skn-1_ratio. |
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