SPELL - Nematode

Citation	Miller EV, Grandi LN, Giannini JA, Robinson JD, Powell JR. The Conserved G-Protein Coupled Receptor FSHR-1 Regulates Protective Host Responses to Infection and Oxidative Stress. PLoS One, 2015.
PubMed ID	26360906
Short Description	The Conserved G-Protein Coupled Receptor FSHR-1 Regulates Protective Host Responses to Infection and Oxidative Stress. GEO Record: GSE72029 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00048530.ce.mr.csv
# of Conditions	12
Full Description	The innate immune system's ability to sense an infection is critical so that it can rapidly respond if pathogenic microorganisms threaten the host, but otherwise maintain a quiescent baseline state to avoid causing damage to the host or to commensal microorganisms. One important mechanism for discriminating between pathogenic and non-pathogenic bacteria is the recognition of cellular damage caused by a pathogen during the course of infection. In Caenorhabditis elegans, the conserved G-protein coupled receptor FSHR-1 is an important constituent of the innate immune response. FSHR-1 activates the expression of antimicrobial infection response genes in infected worms and delays accumulation of the ingested pathogen Pseudomonas aeruginosa. FSHR-1 is central not only to the worm's survival of infection by multiple pathogens, but also to the worm's survival of xenobiotic cadmium and oxidative stresses. Infected worms produce reactive oxygen species to fight off the pathogens; FSHR-1 is required at the site of infection for the expression of detoxifying genes that protect the host from collateral damage caused by this defense response. Finally, the FSHR-1 pathway is important for the ability of worms to discriminate pathogenic from benign bacteria and subsequently initiate an aversive learning program that promotes selective pathogen avoidance. Experimental Details: WBPaper00048530:N2_OP50_prep9 WBPaper00048530:N2_OP50_prep15 WBPaper00048530:N2_OP50_prep30 WBPaper00048530:N2_PA14_prep9 WBPaper00048530:N2_PA14_prep15 WBPaper00048530:N2_PA14_prep30 WBPaper00048530:fshr-1(ok778)_OP50_prep9 WBPaper00048530:fshr-1(ok778)_OP50_prep15 WBPaper00048530:fshr-1(ok778)_OP50_prep30 WBPaper00048530:fshr-1(ok778)_PA14_prep9 WBPaper00048530:fshr-1(ok778)_PA14_prep15 WBPaper00048530:fshr-1(ok778)_PA14_prep30.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: innate immune response