| Citation | Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA. The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes. PLoS Genet, 2015. |
| PubMed ID | 25774872 |
| Short Description | The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes. GEO Record: N.A. Platform: N.A. Download gene-centric, log2 transformed data: WBPaper00046548.ce.mr.csv |
| # of Conditions | 4 |
Full Description
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Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied role in controlling developmental gene expression, the DAF-12 endocrine system governs expression of a gene network that stimulates the aerobic catabolism of fatty acids. Thus, activation of the DAF-12 transcriptome coordinately mobilizes energy stores to permit reproductive growth. DAF-12 regulation of this metabolic gene network is conserved in the human parasite, Strongyloides stercoralis, and inhibition of specific steps in this network blocks reproductive growth in both of the nematodes. Our study provides a molecular understanding for metabolic adaptation of nematodes to their environment, and suggests a new therapeutic strategy for treating parasitic diseases. Experimental Details: WBPaper00046548:Etoh-control_rep1 WBPaper00046548:Etoh-control_rep2 WBPaper00046548:delta7-dafachronic-acid_rep1 WBPaper00046548:delta7-dafachronic-acid_rep2. |
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