| Citation | Kniazeva M, Zhu H, Sewell AK, Han M. A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C.elegans. Dev Cell, 2015. |
| PubMed ID | 25892013 |
| Short Description | A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C.elegans. GEO Record: GSE64973 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00046678.ce.mr.csv |
| # of Conditions | 6 |
Full Description
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Food deprivation suppresses animal growth and development but spares the systems essential for foraging. The mechanisms underlying this selective development, and potential roles of lipids in it, are unclear. When C. elegans hatch in a food-free environment, postembryonic growth and development stall, but sensory neuron differentiation and neuronal development required for food responses continue. Here, we show that monomethyl branched-chain fatty acids (mmBCFAs) and their derivative, d17iso-glucosylceramide, function in the intestine to promote foraging behavior and sensory neuron maturation through both TORC1-dependent and -independent mechanisms. We show that mmBCFAs impact the expression of a subset of genes, including ceh-36/Hox, which we show to play a key role in mediating the regulation of the neuronal functions by this lipid pathway. This study uncovers that a lipid pathway promotes neuronal functions involved in foraging under both fed and fasting conditions and adds critical insight into the physiological functions of TORC1. Experimental Details: WBPaper00046678:elo-5(gk208)_C17ISO-deficient-C13ISO_rep1 WBPaper00046678:elo-5(gk208)_C17ISO-deficient-C13ISO_rep2 WBPaper00046678:elo-5(gk208)_C17ISO_rep1 WBPaper00046678:elo-5(gk208)_C17ISO_rep2 WBPaper00046678:N2_C13ISO_rep1 WBPaper00046678:N2_C13ISO_rep2. |
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