| Citation | Maures TJ, Booth LN, Benayoun BA, Izrayelit Y, Schroeder FC, Brunet A. Males shorten the life span of C. elegans hermaphrodites via secreted compounds. Science, 2014. |
| PubMed ID | 24292626 |
| Short Description | Males shorten the life span of C. elegans hermaphrodites via secreted compounds. GEO Record: GSE51691 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00044535.ce.mr.csv |
| # of Conditions | 11 |
Full Description
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How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites. The male-induced demise could occur without mating and required only exposure of hermaphrodites to medium in which males were once present. Such communication through pheromones or other diffusible substances points to a nonindividual autonomous mode of aging regulation. The male-induced demise also occurred in other species of nematodes, suggesting an evolutionary conserved process whereby males may induce the disposal of the opposite sex to save resources for the next generation or to prevent competition from other males. Experimental Details: WBPaper00044535:glp-1(e2141)_no_males_rep1 WBPaper00044535:glp-1(e2141)_no_males_rep2 WBPaper00044535:glp-1(e2141)_no_males_rep3 WBPaper00044535:glp-1(e2141)_with_males_rep1 WBPaper00044535:glp-1(e2141)_with_males_rep2 WBPaper00044535:glp-1(e2141)_with_males_rep3 WBPaper00044535:glp-1(e2141)_utx-1(RNAi)_no_males_rep1 WBPaper00044535:glp-1(e2141)_utx-1(RNAi)_no_males_rep2 WBPaper00044535:glp-1(e2141)_utx-1(RNAi)_no_males_rep3 WBPaper00044535:glp-1(e2141)_utx-1(RNAi)_with_males_rep1 WBPaper00044535:glp-1(e2141)_utx-1(RNAi)_with_males_rep3. |
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