SPELL - Nematode

Citation	Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature, 2011.
PubMed ID	22012258
Short Description	Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. GEO Record: GSE31043 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00040327.ce.mr.csv
# of Conditions	35
Full Description	Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants. Experimental Details: WBPaper00040327:F4__+_+__from_+_+__rep1 WBPaper00040327:F4__+_+__from_+_+__rep2 WBPaper00040327:F4__+_+__from_+_+__rep3 WBPaper00040327:F4__+_+__from_+_+__rep4 WBPaper00040327:F4__+_+__from_+_+__rep5 WBPaper00040327:F4__+_+__from_+_+__rep6 WBPaper00040327:F4__+_+__from_wdr-5__rep1 WBPaper00040327:F4__+_+__from_wdr-5__rep2 WBPaper00040327:F4__+_+__from_wdr-5__rep3 WBPaper00040327:F4__+_+__from_wdr-5__rep4 WBPaper00040327:F4__+_+__from_wdr-5__rep5 WBPaper00040327:F4__+_+__from_wdr-5__rep6 WBPaper00040327:F4__wdr-5_wdr-5__rep1 WBPaper00040327:F4__wdr-5_wdr-5__rep2 WBPaper00040327:F4__wdr-5_wdr-5__rep3 WBPaper00040327:F4__wdr-5_wdr-5__rep4 WBPaper00040327:F4__wdr-5_wdr-5__rep5 WBPaper00040327:F4__wdr-5_wdr-5__rep6 WBPaper00040327:F5__+_+__from_+_+__rep1 WBPaper00040327:F5__+_+__from_+_+__rep2 WBPaper00040327:F5__+_+__from_+_+__rep3 WBPaper00040327:F5__+_+__from_+_+__rep4 WBPaper00040327:F5__+_+__from_+_+__rep5 WBPaper00040327:F5__+_+__from_+_+__rep6 WBPaper00040327:F5__+_+__from_wdr-5__rep1 WBPaper00040327:F5__+_+__from_wdr-5__rep2 WBPaper00040327:F5__+_+__from_wdr-5__rep4 WBPaper00040327:F5__+_+__from_wdr-5__rep5 WBPaper00040327:F5__+_+__from_wdr-5__rep6 WBPaper00040327:F5__wdr-5_wdr-5__rep1 WBPaper00040327:F5__wdr-5_wdr-5__rep2 WBPaper00040327:F5__wdr-5_wdr-5__rep3 WBPaper00040327:F5__wdr-5_wdr-5__rep4 WBPaper00040327:F5__wdr-5_wdr-5__rep5 WBPaper00040327:F5__wdr-5_wdr-5__rep6.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: aging