| Citation | Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk NJ, Ishioka N, Honda S. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. Sci Rep, 2012. |
| PubMed ID | 22768380 |
| Short Description | Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. GEO Record: GSE36358 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00041267.ce.mr.csv |
| # of Conditions | 5 |
Full Description
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How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues. Experimental Details: WBPaper00041267:GroundControl_OperationSite WBPaper00041267:GroundControl_TsukubaSpaceCenter WBPaper00041267:SpaceFlight WBPaper00041267:ClinoRotation WBPaper00041267:HyperGravity. |
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