SPELL - Nematode

Citation	Sun J, Singh V, Kajino-Sakamoto R, Aballay A. Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes. Science, 2011.
PubMed ID	21474712
Short Description	Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes. GEO Record: GSE27867 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00038304.ce.mr.csv
# of Conditions	6
Full Description	The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPCR, G protein-coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level. Experimental Details: WBPaper00038304:wt_rep1 WBPaper00038304:wt_rep2 WBPaper00038304:wt_rep3 WBPaper00038304:tag-24_rep1 WBPaper00038304:tag-24_rep2 WBPaper00038304:tag-24_rep3.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: innate immune response, Topic: response to unfolded protein