|Citation||Rytinki MM, Lakso M, Pehkonen P, Aarnio V, Reisner K, Perakyla M, Wong G, Palvimo JJ. Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans. Cell Mol Life Sci, 2011.|
|Short Description||Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans. |
GEO Record: GSE19972 Platform: GPL200
Download gene-centric, log2 transformed data: WBPaper00038060.ce.mr.csv
|# of Conditions||9|
|Full Description||Small ubiquitin-related modifiers (SUMOs) are important regulator proteins. Caenorhabditis elegans contains a single SUMO ortholog, SMO-1, necessary for the reproduction of C. elegans. In this study, we constructed transgenic C. elegans strains expressing human SUMO-1 under the control of pan-neuronal (aex-3) or pan-muscular (myo-4) promoter and SUMO-2 under the control of myo-4 promoter. Interestingly, muscular overexpression of SUMO-1 or -2 resulted in morphological changes of the posterior part of the nematode. Movement, reproduction and aging of C. elegans were perturbed by the overexpression of SUMO-1 or -2. Genome-wide expression analyses revealed that several genes encoding components of SUMOylation pathway and ubiquitin-proteasome system were upregulated in SUMO-overexpressing nematodes. Since muscular overexpression of SMO-1 also brought up reproductive and mobility perturbations, our results imply that the phenotypes were largely due to an excess of SUMO, suggesting that a tight control of SUMO levels is important for the normal development of multicellular organisms.