| Citation | Lund J, Tedesco P, Duke K, Wang J, Kim SK, Johnson TE. Transcriptional profile of aging in C. elegans. Curr Biol, 2002. |
| PubMed ID | 12372248 |
| Short Description | Transcriptional profile of aging in C. elegans. GEO Record: GSE4005 Platform: GPL2653 GPL2655 GPL3096 GPL3097 GPL3098 Download gene-centric, log2 transformed data: WBPaper00005475.ce.mr.csv |
| # of Conditions | 6 |
Full Description
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Background: Numerous gerontogene mutants leading to dramatic life extensions have been identified in the nematode Caenorhabditis elegans over the last 20 years. Analysis of these mutants has provided a basis for understanding the mechanisms driving the aging process(es). Several distinct mechanisms including an altered rate of aging, increased resistance to stress, decreased metabolic rate, or alterations in a program causing organismic aging and death have been proposed to underlie these mutants. Results: Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1 % of the genome). Expression of heat shock proteins decreases, while expression of certain transposases increases in older worms, and these findings are consistent with a higher mortality risk due to a failure in homeostenosis and destabilization of the genome in older animals. Finally, a specific subset of genes is coordinately altered both during chronological aging and in the transition from the reproductive form to the dauer, demonstrating a mechanistic overlap in aging between these two processes. Conclusions: We have performed a whole-genome analysis of changes in gene expression during aging in C. elegans that provides a molecular description of C. elegans senescence. Experimental Details: [cgc5475]:day12-14 [cgc5475]:day16-19 [cgc5475]:day3 [cgc5475]:day4 [cgc5475]:day6-7 [cgc5475]:day9-11. |
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