| Citation | Reinke V, Smith HE, Nance JF, Wang JL, Van Doren C, Begley RR, Jones SJM, Davis EB, Scherer S, Ward S, Kim SK. A global profile of germline gene expression in C. elegans. Mol Cell, 2000. |
| PubMed ID | 11030340 |
| Short Description | A global profile of germline gene expression in C. elegans. GEO Record: GSE5 Platform: GPL14 Download gene-centric, log2 transformed data: WBPaper00004349.ce.mr.csv |
| # of Conditions | 13 |
Full Description
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We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not. Experimental Details: [cgc4349]:fem-3_fem-1 [cgc4349]:glp-4_reference_adult [cgc4349]:glp-4_reference_L2 [cgc4349]:glp-4_reference_L3 [cgc4349]:glp-4_reference_L4 [cgc4349]:WT_glp-4_adult [cgc4349]:WT_glp-4_L2 [cgc4349]:WT_glp-4_L3 [cgc4349]:WT_glp-4_L4 [cgc4349]:WT_reference_adult [cgc4349]:WT_reference_L2 [cgc4349]:WT_reference_L3 [cgc4349]:WT_reference_L4. |
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